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Fernndez-Barrena MG, Arechederra M, Colyn L, Berasain C, Avila MA

Tipple, T

[231] engineered N-series LNPs featuring amide-bonded tails to achieve selective mRNA delivery to the lungs, addressing the liver-centric targeting limitations of conventional LNPs

In a first part, I discuss biological issues related to the persistence of microbial antigens, dysregulated immune responses, reactivation of latent viruses, different potential self-sustained inflammatory loops, mitochondrial dysfunction, metabolic disorders in the tryptophan- kynurenin pathway (TKP) with impact on serotonin, and consequences of a dysfunctional bidirectional microbiota-gut-brain axis