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doi: 10.7326/0003-4819-151-4-200908180-00136

Lastly, coagulation defects in cirrhosis, manifesting as petechiae, ecchymoses, or mucosal bleeding, are due to thrombocytopenia and other hemostasis abnormalities, like those seen in hematologic disorders and anticoagulant therapy for thrombotic diseases

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While gastrointestinal symptoms (nausea, vomiting, diarrhea, constipation) affect many patients initially, severe or persistent symptoms may necessitate dose adjustment, temporary dose reduction, or consideration of alternative therapies

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