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They are made by different companies (Innovent Biologics and Eli Lilly, respectively), have different clinical trial programs, and produce different levels of weight loss

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Beta-3 receptors are highly expressed in adipose tissue but have limited expression in most other tissues in adult humans

These findings align with previous reports indicating that downstream pathways, particularly PI3K/AKT and mTOR, are responsive to hepsin downregulation (Fig