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References: Sitohang, I

Abstract Copper ions play various roles in mammalian cells, presumably due to their involvement in different enzymatic reactions

Processes such as microglial activation and migration, upregulation of pro-inflammatory cytokines, sealing of the injured area through glial scar formation, leucocyte chemotaxis, and infiltration, increase in blood-brain barrier (BBB) permeability, and recruitment of adaptive immunity mechanisms characterize the early environment of the brain in the acute and sub-acute phase of stroke (Morioka et al., 1993

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