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Vitamin B12 is also important for DNA synthesis and your brain's and nerve cells' normal functions

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Interestingly, the stage of plaque macrophage progression depends on the intensity of monocyte myelopoiesis and macrophage proliferation, the increased expression of chemokines and the expression of several inhibitor molecules for migration within the plaque, including netrin-1 (142)

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However, long-term use is associated with challenges such as motor fluctuations, dyskinesias, and loss of therapeutic efficacy due to progressive neurodegeneration and alterations in dopaminergic pathways