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Changing brands of vitamin B12, forms of B12 (cyanocobalamin vs hydroxocobalamin), or switching from injections to tablets can be a solution in those (rare) cases

The example math below uses 3.0 mL of bacteriostatic water per 50 mg vial, which gives roughly 16.7 mg/mL of compound in solution

[PubMed] Kannengiesser K, Maaser C, Heidemann J, et al

Research studies have demonstrated reductions in body weight gain and increased lipolytic activity in adipose tissue

Higher amounts are recommended for pregnant women and breastfeeding women
