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There are multiple proposed mechanisms for its use in ALS, including mitigating oxidative stress by up-regulating nuclear factor erythroid 2-related factor 2 (Nrf2), glutathione, and heme oxygenase 1 (HO-1) [175], promoting mitochondrial function by increasing serum levels of ATP [176], and protecting against glutamate excitotoxicity [177]

Sag, Dimitrie Siriopol, Masanari Kuwabara, Silvia Badarau, Adrian Covic, Alberto Ortiz Journal of Nephrology.2021

doi: 10.1177/0883073819875915 80

100g Powder

This grinding was traditionally performed by chewing the roots and spitting them out, but now its typically done by hand ( The paste is then mixed with water, strained, and consumed