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doi: 10.7150/ijbs.41051 102 LiXGracillaDCaiLZhangMYuXChenXet al

Major contributors to ROS production include mitochondrial dysfunction, cytochrome P450 2E1 (CYP2E1), and NADPH oxidase (NOX) enzymes

The following were the inclusion criteria: male and female adult patients aged 18 to 65 years with mild to moderate psoriasis in the active phase (PASI 5 for mild psoriasis and 510 for moderate psoriasis) [33]

[DOI] [PubMed] [Google Scholar] 109.De Pergola G., Triggiani V., Bartolomeo N., Giagulli V.A., Anelli M., Masiello M., Candita V., De Bellis D., Silvestris F

Under oxidative stress, DNA methyltransferases DNMT1 and DNMT3B, along with sirtuin SIRT1, relocate to CpG islands (CGIs) and form complexes with PRC2 subunits like EZH2 and EED, leading to localized DNA methylation (172)