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Long-chain saturated free fatty acids (FFAs) produced by reactive astrocytes promote OL death in culture 116

doi: 10.1016/j.biopha.2019.109596

Shake thoroughly for up to 30 seconds check the lid to ensure all the powder has been mixed into the solution

Companies choose Paragraph III when they judge that the listed patent is robust enough that a Paragraph IV challenge is unlikely to succeed, when the commercial value does not justify the litigation cost, or when they want to queue up an approval that will be immediately effective on the expiration date

A detailed history is crucial, as latency between exposure and enzyme elevation may span months