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In addition to the characteristic rash, features of classical lupus include: Profound fatigue that is unresponsive to rest Arthralgia in multiple joints and edema in multiple joints Spontaneous fever Photosensitivity in which sun exposure precipitates or aggravates the disease Alopecia or hair loss Mucous membrane lesions Raynaud's phenomenon, in which fingers and toes turn blue and white in cold temperatures Lupus complications arise when the disease infects organs of the body's middle segment

2021 Mar About the Author Katie is a qualified Naturopath (BNatMed) and freelance writer from New Zealand

Ongoing research is also focusing on identifying new targets, investigating the effectiveness of combination therapies, and exploring the use of targeted radiotherapy on tumor stem cells

The second-order neurons express orexigenic peptides that are melanin-concentrating hormone (MCH) and orexins A and B