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Mutation spectrum of NOD2 reveals recessive inheritance as a main driver of Early Onset Crohns Disease

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All members of this family are conjugated to phosphatidylethanolamine (PE) in the membrane of the growing phagophore (referred to as lipidation) by ATG7 (an E1-like enzyme), ATG3 (an E2-like enzyme), and the ATG12-ATG5-ATG16L1 complex (an E3-like enzyme) 10

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This heightened expression has been observed to result in a substantial reduction in patient survival, a phenomenon that is attributed to the enzymes capacity to enhance glutamine metabolism within cancerous cells