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As nasal cavity dimensions vary from person-to-person (depending on nasal congestion), its no surprise that some people dont respond to intranasal medication

Cytosolic malic enzymes (ME1/MEc) catalyze the reversible oxidative decarboxylation of L -malate to produce pyruvate and CO 2 with the reduction of NAD + or NADP + to NADPH [84]: NADPH produced from the MEc is utilized for the long-chain fatty acids synthesis

This will enhance early detection and prevention of DR and significantly improve patient prognosis and quality of life through personalized treatment

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