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A higher serum MOTS-c concentration is associated with greater muscle mass, force, and power generated during jumping in healthy individuals but not exercise capacity reflected by peak VO2

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Tesofensine, by contrast, is a triple monoamine reuptake inhibitor (blocking dopamine, norepinephrine, and serotonin reuptake) that increases resting energy expenditure by 1015% above baseline

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The 1mg dose also serves a critical role as the universal starting point for all titration schedules