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Both the levels of glutamate transporters GLAST and GLT-1 released by astrocytes, as well as the expression of GS are altered as a consequence of the ageing process, contributing to increased glutamate excitotoxicity ( Similar to some neurodegenerative diseases, astrocyte activation during senescence is mainly observed in specific areas where there is greater synaptic loss and age-related cognitive decline, such as the hippocampus and frontal cortex frontal (Rodrguez et al., 2016

doi: 10.1080/01443615.2019.1603215

In vivo imaging of glutamine metabolism to the oncometabolite 2-hydroxyglutarate in IDH1/2 mutant tumors

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