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Spaderna S, Schmalhofer O, Wahlbuhl M, Dimmler A, Bauer K, Sultan A et al

Katsuyama Y, Hiyama K, Sawamura A, Kawase I, Okano Y, Masaki H

The short answer is: it depends on your skin type, dosage, frequency, and overall health

For the nitrated octadecanoids, effects are also initiated from multiple interactions including those at nuclear receptors (e.g., Nrf2, PPARs, NFB, heat shock response, stimulator of interferon genes (STING)), and cellular receptors (e.g., angiotensin II type 1 receptors), as well as by direct modulation of enzyme activity (e.g., soluble epoxide hydrolase (sEH), 5-LOX, xanthine oxidase)

doi: 10.1016/0891-5849(92)90147-9