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324 ZhengG.FilippelliG

Carotenoids, such as -carotene, lutein, astaxanthin, and lycopene, not only have antioxidant effects but can also be converted into Vitamin A, participating in a variety of physiological processes [418]

Key research considerations include: Glycemic durability: Persistent HbA1c reductions without rebound hyperglycemia Cardiovascular signaling: Improvements in lipid parameters and blood pressure, indicating systemic metabolic benefits High-risk populations: Variable responses among individuals with elevated BMI and insulin resistance, offering insight into personalized metabolic research approaches Collectively, Phase 3 evidence positions retatrutide as a valuable tool for expanding the understanding of glucagon signaling beyond its traditional role in glucose regulation

Nolan, B

T., Jian W