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This means giving as much thought to what we leave out as to what we put in

The substantial amount is at least 70 - 80 % in 10 - 12 hrs, preferably at least 90 % in 12 hrs and most preferably at least 95 % in 12 hrs

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This category is defined as: "Any pharmacological substance which is not addressed by any of the subsequent sections of the List and with no current approval by any governmental regulatory health authority for human therapeutic use (e.g

this depends on the individuals metabolism, lifestyle, and the specific treatment