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Keogh JP, Steffen B, Siegers CP

Pierce GST Spin Purification Kit, 3 mL

Among phytochemicals, flavonoids and polyphenols play pivotal roles in detoxification mechanisms by upregulating antioxidant enzymes, including Glutathione S-Transferase (GST), NAD(P)H Quinone Dehydrogenase 1 (NQO1), and Superoxide Dismutase (SOD), while simultaneously suppressing pro-inflammatory pathways

This work elucidates distinct metabolic states in SCLC and suggests new approaches to induce cell death in this lethal form of cancer

In particular, GSDME-deficiency significantly attenuated the hippocampal atrophy and changed levels of DAM markers in GCLC-KO mice