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Subsequently, the expression of Drp1 and Fis1 was up-regulated, while down-regulated expression of Opa1 and Mfn1 was observed, which indicated the effect of silibinin to enhance mitochondrial fission and to weaken mitochondrial fusion
2013 Sept
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37 Garcia, A
Besides, clinical outcomes have often been less robust than preclinical data suggested, partly due to the complexity of AMLs genetic and epigenetic heterogeneity, the limitations of model systems, and intrinsic resistance mechanisms
