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Description
In autophagy regulation, selective activation of the PINK1/Parkin pathway enhances ubiquitination and clearance of damaged mitochondria, increasing levels of the autophagosome marker LC3-II [102], which could serve as a pharmacodynamic biomarker in preclinical models
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Poor oral bioavailability is one of the greatest obstacles: curcumin is quickly eliminated in the liver and intestines to glucuronide and sulfate conjugates, which leads to low systemic exposure, short plasma half-life and low tissue penetration [12]
J Nat Prod 2020, 83 (12), 35983605
