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Both of the double blinded randomised intervention trials provided information about concealment and the laboratory was blinded thereby reducing performance and detection bias [64, 65]

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Clinical and MRI evolution after local injection of bone marrow-derived mesenchymal stem cells in perianal fistulae in Crohns disease: Results from a prospective monocentric study

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In addition, mtDNA that is released into the cytoplasm can not only activate cyclic GMP-AMP synthase (cGAS) or Toll-like receptors 9 (TLR9) to promote the production of IFNs (86, 87) but also serve as an antigen to directly activate the immune system to exacerbate autoantibody production (81)