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Although some in vitro studies have suggested that opiates diminish endogenous interferon alfa production191, there are several studies of persons taking methadone that suggest that the drug does not significantly reduce the likelihood of an SVR, nor alter the dosing of interferon alfa or ribavirin192, 193

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The ACADL gene is located on chromosome 2q34 and is composed of 12 exons that encode a 430 amino acid precursor protein