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Regarding the route of administration, it was agreed that the acuity and severity of the symptoms of vitamin B12 deficiency necessitate prioritizing treatment with parenteral vitamin B12

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Any treatment is provided only after a comprehensive evaluation by a licensed medical provider

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There were inhibited mRNA of inflammatory mediators (iNOS, IL-6, IFN and TNF-), increased expression of HSP 70 and 90, and antioxidant proteins, such as HO-1, NQO-1, glutathione reductase, glutathione peroxidase 2 and GST-pi [30]