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In cases of resistant tumors harboring JAK mutations that impair IFN signal transduction, novel immunotherapeutic approaches that bypass this defective pathway (such as those leveraging IFN-independent cytotoxic mechanisms) or bispecific antibodies offer a critical strategy to overcome treatment resistance

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[DOI] [PubMed] [Google Scholar] 68.Checa-Rojas A., Delgadillo-Silva L.F., Velasco-Herrera M.D.C., Andrade-Dominguez A., Gil J., Santillan O., Lozano L., Toledo-Leyva A., Ramirez-Torres A., Talamas-Rohana P., et al

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