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Notably, a recent study identified copper-associated proteotoxic stress [8] that may also be involved in the pathogenesis of CVD

Spine 20 (11), 13071314

[DOI] [PMC free article] [PubMed] [Google Scholar] 113.Sudhakaran G., Kesavan D., Ranjan Nayak S.P.R., Madesh S., Meenatchi R., Pachaiappan R., Almutairi M.H., Almutairi B.O., Arockiaraj J

Perhaps a comparative analysis with other drugs with a similar mechanism of action, such as vedolizumab, would contribute to a better assessment of efficacy and safety and aid in selecting the optimal, personalized therapy for a specific patient [56]

Articular cartilage is primarily composed of chondrocytes and an extracellular matrix (ECM), which consists mainly of type II collagen and proteoglycans ( Synovial inflammation and immune dysregulation are also characteristic of OA
