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Morris, G., et al., The Glutathione System: A New Drug Target in Neuroimmune Disorders

Inactive cereblon-based PROTACs After the discovery that thalidomide derivatives with N-alkylated glutarimide ring are unable to establish binding with cereblon E3 ligase, many research groups began to incorporate these derivatives in the construction of PROTACs with the aim of obtaining negative controls, and thus assessing whether PROTAC-induced degradation is or is not cereblon-dependent 52,189

Phospholipid peroxidation inhibits autophagy via stimulating the delipidation of oxidized LC3-PE

The interpretation of IGF-1 assay results is yet further complicated by the lack of a comprehensive set of reference ranges that define normal circulating levels across multiple populations

Introducing the concept of ferroptosis provides insights into a new pathogenic mechanism of iron-mediated diseases, encouraging researchers to delve deep into it