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In addition, as was previously reported, we observed an increase in the expression of SOD2, which is known to be involved in the mitochondrial oxidative stress pathway 14
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Epilepsia 49:256268
While ACMSD knockdown improves cognitive recovery in aged mice [255], therapeutic translation requires careful calibration: excessive pathway activation risks accumulating neurotoxic quinolinic acid, potentially exacerbating anxiety symptoms [256,257,258,259,260,261,262,263] (Table S6)
