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7 That temporal pattern worst early, easing later is clinically important on two counts

Major classes of drugs currently in clinical trials include neuroprotectants, stem cell therapies, tau vaccines, humanized antibodies, metabolic modulators, neurotransmitter modulators, DNA modifications, anti-hypertensives, NSAIDs, and a host of various remedy and vitamin treatments [29]

Haqqani, A

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Paclitaxel also impaired reversal learning tasks (Smith et al., 2017), with rats treated with paclitaxel unable to rapidly adapt to new experimental contingencies