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In the nucleus, following heterodimer complex formation with transcription factors, like small Maf proteins (G/F/K) and c-Jun, Nrf2 complexes bind to the antioxidant response element (ARE), a regulatory enhancer region within gene promoters that upregulate antioxidant and anti-inflammatory defense processes (Cuadrado et al., 2019

Because impaired NVC responses have also been linked to changes in gait coordination both in preclinical models [52] and older adults [80], future studies should also determine how IGF-1related changes in NVC relate to subclinical alterations in gait

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