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Numerous studies have reported that NNMT has an inhibitory effect on the aerobic metabolism of sugars and fats, and NNMT Knockdown can increase oxygen consumption, promote sugar consumption and reduce fat synthesis, but the effects of NNMT on anaerobic energy metabolism have not been reported

This would be a significant deviation from how nutrient recommendations are normally formulated which is to base them on most peoples needs rather than outlier cases that require special treatment

Polycythemia vera, a rare blood disorder, where careful medical oversight is appropriate

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