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Semaglutide (Wegovy) and liraglutide (Saxenda) work by mimicking the glucagon-like peptide-1 hormone, which regulates appetite and food intake

In individuals that underwent bariatric surgery, lipid age increased in patients with weight regain, while lipid age decreased in individuals with stable weight (235)

A few more well-studied factors stand out

Free radicals play a direct role in this breakdown
