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Description
Advanced chemical engineering techniques are being used to develop derivatives with enhanced stability and cellular penetration

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The initial step in reabsorption involves tight binding of folate to FOLR1 (folate receptor alpha, FR-) that is highly expressed at the luminal apical brush-border membrane of proximal tubules

PMID: 183 ParidaPKMarquez-PalenciaMNairVKaushikAKKimKSudderthJet al

As of now, only small-scale case studies have been conducted for IN administration of iron chelators, but more progress in clinical translation is anticipated
