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Neuroanatomy of extrinsic afferents supplying the gastrointestinal tract

10.14573/altex.2108301 98 RajagopalR.BaltazarM

Current research has moved beyond demonstrating the efficacy of single strains and now focuses on designing multimodal, precision interventions, marking a shift from discovery to design

Iberdomide (CC-220) is a potent cereblon E3 ligase modulator with antitumor and immunostimulatory activities in lenalidomide- and pomalidomide-resistant multiple myeloma cells with dysregulated CRBN

however, excessive ferroptosis leads to cellular hypoxia and nutrient deprivation, triggering inflammation-related immunosuppression within the TME and thereby promoting tumor cell proliferation