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5 As previous investigations have found no significant histopathological changes associated with minor aminotransferase elevations in patients started on statins, the changes have recently been termed hepatic adaptations rather than injury

It is known that NAFLD is associated with an imbalance in a variety of metabolic networks, among which abnormal lipid metabolism is the core pathological metabolic process (49)

When IGF-1 axis is activated, multiple signaling pathways corresponding to its kinase domain are also activated, including PI3K/Akt pathway and Raf/MEK/ERK level linkage pathway, which can ultimately reduce IR and prevent cell apoptosis (58, 59), thereby improving NAFLD

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J Comp Neurol 1999