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Infiltrating immune cells either exhibit anticancer responses or create an immunosuppressive environment (105)

These resistant cells upregulate lipid ROS-detoxifying enzymes such as GPX4 and FSP1, and knockdown of GPX4 in these resistant cells re-sensitizes them to both ferroptosis and TMZ [155], highlighting a glioblastoma-specific therapeutic vulnerability that emerges from alkylating agent adaptation

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Excess ROS production can negatively affect the immune system and overall health status of birds
