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A further challenge is posed by the high production cost of synthetic AMPs, especially those with complex structures or those which contain unnatural amino acids [180]
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Moreover, miR-103a-3p, miR-30b-5p, and miR-29a-3p exhibited high levels of expression after Levodopa treatment, suggesting the role of miRNAs as disease modifier agents in PD (Serafin et al., 2015)
Typically, patients are diagnosed at an advanced stage, and systemic therapies are recommended as the standard treatment [7]
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