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Many people notice increased energy and mental clarity within 24-48 hours

Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association

SPY might be useful for short-term trading due to its higher volume and tighter bid-ask spreads, but VOO is the (admittedly only slightly) better long-term holding due to lower costs, better compounding, and higher tax-efficiency for those investing in taxable accounts

doi: 10.1038/nchembio.2307