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All of these are developed and designed to be done under simple local anesthesia in the office, typically take 15 minutes or less to perform, usually offer a 75-85% success rate, and have minimal to very low risk of complications

Moreover, the relationship between DN and other complications, such as cardiovascular autonomic neuropathy, has been established, indicating that these conditions often coexist and may share common pathophysiological mechanisms (de Paula et al., 2024

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