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Serious adverse events were rare and not dose-dependent
All non-protein-bound B12 is quickly excreted by the kidneys

On the origin of biochemistry at an alkaline hydrothermal vent

2017;95(3):323 to 333

FEBS Open Bio 2:298304 Hashimoto W, Suzuki H, Nohara S, Kumagai H (1992) Escherichia coli gamma-glutamyltranspeptidase mutants deficient in processing to subunits
