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Reconstituted cagrilintide stored at 2-8C remains stable for 28 days
MOR-LTD of presynaptic FSI PV-expressing neurons inhibit GABAergic input to pyramidal neurons of medial, but not lateral OFC
In a phase-3 trial including over 2500 overweight and obese individuals (baseline weight 233lb on average), the subjects achieved up to a 20.9% (about 48lb) mean reduction in body weight after 72 weeks at the dose of 15mg/weekly [11]
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