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This was demonstrated by Seet et al

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2.7 Phenotypic analysis of macrophage polarization and activation Macrophage activation state was determined by intracellular staining for TNF- and IFN- at 0 dpc (immediately after the 18-h coculture), and by surface staining for CD80-PE (BioLegend
Extending from these conceptual and mechanistic insights, PRLM analogs, such as RvE1 mimetics, have advanced to phase I/II clinical trials, primarily to assess long-term safety, pharmacokinetics, and therapeutic windows [18]

In a trial, 36 healthy subjects took 200 mg, 400 mg, or 600 mg of Bai tablets
