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Of note, GPX4 deficient mice are not viable and die at embryonic day 8 [3, 4]

Microsoft Corp, Redmond, WA) were used for the data extraction method

Preclinical studies have shown that several dual IGF-1R/IR RTKi, including OSI-906 (linsitinib) [159], BMS-554417 [148], and BMS-754807 [160,161], exhibit anti-proliferative and pro-apoptotic affects in breast tumor cells, and inhibit breast tumor growth in vivo when given alone or in combination with hormone therapy

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