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Circulating levels of TMAO are influenced by variations in the ability of the gut microbiota to produce TMA

Gazit N, Vertkin I, Shapira I, Helm M, Slomowitz E, Sheiba M, et al

An additional limitation of proteinuria is that its associated with rapid progression but that is not always present in CKD or may vary in different CKD stages ( Metabolomic studies in CKD found TMAO is a potential biomarker that may help identify CKD patients (Tang et al., 2015), and TMAO has a strong association with CKD in a validation study, 80% sensitivity with other six urinary metabolites including glutamate, guanidoacetate, and -phenylacetylglutamine (all increased in CKD), 5-oxoproline, taurine, and citrate (all decreased in CKD) (Posada-Ayala et al., 2014)

Do not exceed the recommended maximum daily dose

In effect, it reduces the overall chatter between nerves