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Structural Diversification of Natural Products In the previous sections, we summarized the impact of synthetic biology on the genome mining of natural products and enzymes discovery, both in the native producing host and in model heterologous hosts

major targets is presented in Tables 1 and 2, the list of 254 FDA-approved drugs (henceforth referred to as 'Lm254') is presented in Additional file 1: Table S2, and the list of all drugs associated with the 8 synthetic lethal targets is presented in Additional file 1: Table S3

Statements Author contributions XP: Conceptualization, Supervision, Investigation, Writing review & editing, Software, Methodology, Funding acquisition, Formal analysis, Visualization, Data curation, Writing original draft

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394,395 As mentioned above, HSF1 is subject to numerous PTMs that govern its activation or inhibition at different levels, and the mediators of these PTMs themselves, or their upstream receptors or sensors, help integrate multiple different stimuli in the HSF1-mediated response