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1d) and kept the fast plasma insulin level at normal levels (Fig

The pre-bed injection is widely considered the most important administration window, as it amplifies the body's largest natural GH pulse during deep sleep

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Mechanistically, Nrf2 activation leads to transcriptional activation of antioxidant enzymes, including microsomal epoxide hydrolase, heme oxygense-1 (HO-1), NADPH: quinone oxidoreductase 1 (NQO-1), and glutamate cysteine ligase (GCL), which catalyzes the initial and rate-limiting step in GSH synthesis

F., Smith, B