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In accordance to the activation of HIF-1 (Figure 5A), roxadustat significantly increased the PFKFB3 expression on mRNA and protein level in a dose-dependent manner in both neurons and astrocytes (Figure 8B)

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& Okeefe, J

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[DOI] [PMC free article] [PubMed] [Google Scholar] 319.Shamovsky I., Nudler E

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