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doi: 10.1021/acsnano.3c10797

ST preconditioning can inhibit NLRP3 inflammasome- mediated pyroptosis by modulating the PI3K/AKT/NF-B signaling pathway, to exert beneficial effect on CIRI-induced neuronal loss, neuroinflammation and oxidative stress

Ihegboro, J

Furthermore, pharmacokinetic interactions involving P-gp inhibitors, such as verapamil and ketoconazole, can also lead to elevated brain-to-plasma concentration ratios of co-administered P-gp substrates in both preclinical and clinical settings, raising concerns about potential neurotoxicity and altered efficacy (170)

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