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Cyanocobalamin dose for dogs is generally used in dogs with known or suspected deficiency, and those with chronic gastrointestinal (GI) disease, exocrine pancreatic insufficiency (EPI), intestinal dysbiosis, inflammatory bowel disease (IBD), malabsorption disease, severe malnutrition, or some inherited conditions that affect vitamin B12 absorption

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The hypersensitivity is thought to be mediated by immunoglobulin E (IgE) or sensitization to the vitamin B12 molecule itself