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The decreased neuronal cell potential would lead to opening of voltage-gated Ca 2+ channels that would allow Ca 2+ , at 1.5 10 4 greater concentration outside the neuron compared to intraneuronal Ca 2+ concentration, to rush into the neuron, overwhelming intracellular storage sites and activating necrotic and apoptotic pathways (6, 139)

The third reaction involves the dehydrogenation by TMABA dehydrogenase (TMABADH) to form 4- N -trimethylaminobutyrate (butyrobetaine)

Viceversa, in individui sani con livelli muscolari adeguati, la carnitina raramente rappresenta il principale fattore limitante dellossidazione dei grassi

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