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Disulfidptosis is a regulatory form of cell death induced by disulfide stress (Liu et al., 2023a), which is caused by an imbalance of the intracellular glutathione and thioredoxin antioxidant systems, leading to the accumulation of disulfide bonds
Under normal conditions, NRF2 is bound to Kelch-like ECH-associated protein 1 (Keap1) in the cytosol
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